Rapid discontinuation has also been associated with attempts to find other sources of opioid analgesics, which may be confused with drug-seeking for abuse. Rapid discontinuation of opioid analgesics in patients who are physically dependent on opioids has resulted in serious withdrawal symptoms, uncontrolled pain, and suicide.
Safe Reduction or Discontinuation of Oxycodone Hydrochloride and Acetaminophen Tablets and Oral Solutionĭo not abruptly discontinue ENDOCET in patients who may be physically dependent on opioids. The relative bioavailability of Oxycodone Hydrochloride and Acetaminophen Tablets or Oral Solution compared to extended-release oxycodone is unknown, so conversion to extended-release oxycodone must be accompanied by close observation for signs of excessive sedation and respiratory depression. Strengthġ or 2 tablets every 6 hours as needed for painġ tablet every 6 hours as needed for painĬonversion from Oxycodone Hydrochloride and Acetaminophen to Extended-Release Oxycodone The total daily dose of acetaminophen should not exceed 4 grams.
The usual adult dosage is one tablet every 6 hours as needed for pain. Initiate treatment with ENDOCET tablets 2.5 mg/325 mg adult dosage, with one or 2 tablets every 6 hours as needed for pain. Ĭonsider prescribing naloxone when the patient has household members (including children) or other close contacts at risk for accidental ingestion or overdose. The presence of risk factors for overdose should not prevent the proper management of pain in any given patient. Inform patients and caregivers about the various ways to obtain naloxone as permitted by individual state naloxone dispensing and prescribing regulations (e.g., by prescription, directly from a pharmacist, or as part of a community-based program).Ĭonsider prescribing naloxone, based on the patient’s risk factors for overdose, such as concomitant use of CNS depressants, a history of opioid use disorder, or prior opioid overdose. Patient Access to Naloxone for the Emergency Treatment of Opioid Overdoseĭiscuss the availability of naloxone for the emergency treatment of opioid overdose with the patient and caregiver and assess the potential need for access to naloxone, both when initiating and renewing treatment with ENDOCET. Monitor patients closely for respiratory depression, especially within the first 24 to 72 hours of initiating therapy and following dosage increases with ENDOCET and adjust the dosage accordingly. Initiate the dosing regimen for each patient individually, taking into account the patient's severity of pain, patient response, prior analgesic treatment experience, and risk factors for addiction, abuse, and misuse.
Use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals. Important Dosage and Administration Instructions
0 kommentar(er)
